Overview
Adnexal masses are cysts or growths that form in the ovaries and surrounding tissues. The vast majority are benign, and functional cysts, which are especially common in women of childbearing age, disappear on their own.
Symptoms may include pelvic pain, a feeling of fullness in the abdomen, and menstrual irregularities. The first step in diagnosis is ultrasonography. In suspicious cases, MRI and blood tests are used.
Treatment varies depending on the characteristics of the mass. While benign small cysts are monitored, large masses that cause symptoms or carry suspicion of cancer are surgically removed. During surgery, ovarian tissue is preserved as much as possible.
In the postmenopausal period, masses carry a higher risk of cancer and therefore require more careful evaluation. Regular gynecological checkups are vitally important for early detection and appropriate management of adnexal masses.
Types of Adnexal Masses
Understanding what types exist helps you make sense of adnexal masses. Each type has different characteristics.
- Functional Cysts. These are the most common types and form as part of the normal ovulation cycle. Each month your ovaries grow a follicle (small sac) for egg release. Sometimes this follicle can become larger than normal or accumulate fluid after releasing the egg. These cysts usually disappear on their own within 2-3 months. They may cause no symptoms or mild pain.
- Dermoid Cysts (Teratoma). These are cysts present from birth but usually grow during adulthood. They can contain different tissue types like hair, teeth, skin, or fat tissue because they develop from embryonic cells. They're more common in young women. Most are benign but rarely can be cancerous.
- Endometrioma (Chocolate Cyst). These are cysts associated with endometriosis. They form when tissue that lines the inside of the uterus (endometrium) grows in the ovary. They're dark brown in color because they're filled with old blood and are called "chocolate cysts." They can cause pain and infertility.
- Polycystic Ovary Syndrome (PCOS) Cysts. In PCOS, the ovaries develop many small cysts. This creates hormonal imbalance and causes irregular periods, weight gain, and excess hair growth.
- Ovarian Tumors. These are abnormal growths of ovarian tissue. They can be benign or malignant (cancerous). Benign types include cystadenoma and fibroma. Malignant ones are ovarian cancer.
- Fallopian Tube Problems. Rarely, cysts or tumors can form in the fallopian tubes. Also, ectopic pregnancy (pregnancy outside the uterus) can appear like an adnexal mass.
- Pelvic Inflammatory Disease (PID). Infection can cause abscess (pus collection) in the ovaries or tubes. This is also detected as a mass.
Symptoms
Many adnexal masses cause no symptoms. Especially small functional cysts are usually silent and found incidentally during routine exams. However, some masses can create various symptoms.
Possible symptoms include:
- Abdominal or pelvic pain. If the mass is large or creating pressure, persistent or intermittent pain may be felt in the lower abdomen or pelvis. Pain is usually one-sided - on the side where the mass is located. Some women describe a constant dull ache, others sharp cramps.
- Sudden severe pain. If the mass twists around its own axis (ovarian torsion), sudden, sharp, severe pain begins. This is an emergency. Or if a cyst ruptures, sudden pain can also occur.
- Abdominal bloating or fullness. Large masses create abdominal bloating. You may notice your abdomen is swollen or your clothes feel tight.
- Pressure sensation. If the mass is pressing on the bladder, you may need to urinate frequently. If pressing on the bowels, constipation or difficulty with bowel movements may occur.
- Menstrual irregularities. Some masses disrupt hormonal balance and affect the menstrual cycle. Periods may be irregular, skipped, or heavier than normal.
- Painful intercourse. If the mass is in the pelvic area, it can create pain during sexual intercourse.
- Bloating and gas. If the mass is pressing on the digestive system, bloating, gas, and nausea may occur.
None of these symptoms are specifically unique to adnexal masses. The same symptoms can arise from other conditions. So if you have any of these symptoms, definitely consult your doctor.
When to See a Doctor
Some situations require emergency care:
- Sudden onset severe abdominal or pelvic pain (may be a sign of ovarian torsion or cyst rupture)
- Pain accompanied by fever, nausea, or vomiting
- Fainting or dizziness
- Rapid heartbeat or shortness of breath
Non-emergency but evaluation-requiring situations:
- Persistent abdominal or pelvic pain
- Abdominal bloating or growth
- Menstrual irregularities
- Frequent urination or constipation
- Painful sexual intercourse
- Unexplained weight loss
Regular gynecological exams are important. Many adnexal masses are found incidentally during routine checkups.
Causes
The cause of adnexal masses varies by type.
- Hormonal fluctuations. Functional cysts are part of the normal hormonal cycle. During ovulation, the ovaries grow follicles. Sometimes these follicles become larger than normal or accumulate fluid after ovulation.
- Endometriosis. Uterine lining tissue growing in places like the ovary leads to endometrioma formation. Why endometriosis develops in some women isn't fully understood, but genetic and immune factors play a role.
- Hormonal imbalances. Conditions like PCOS disrupt hormonal balance and cause many small cysts to form.
- Pregnancy. A corpus luteum cyst (yellow body) normally forms in early pregnancy and usually disappears in the second trimester.
- Infections. Sexually transmitted infections can lead to pelvic inflammatory disease and abscess formation may occur.
- Genetic factors. Some mass types, especially dermoid cysts and some tumors, are associated with genetic predisposition.
- Age. Functional cysts are very common in women of reproductive age. In postmenopausal women, functional cysts don't form because ovulation stops, but other mass types can occur.
Diagnosis
Adnexal mass diagnosis happens in several steps.
Gynecological exam. Your doctor performs a pelvic exam. They check for swelling or masses in the ovaries through vaginal and abdominal manual examination. However, small masses may not be felt by hand.
Ultrasound. This is the most important diagnostic tool. Ultrasound done through the abdomen or vaginally shows the mass's size, location, content (fluid or solid), and characteristics. Your doctor gets clues from ultrasound about whether the mass is benign or malignant.
Blood tests. Some blood tests may be done:
- CA-125: Ovarian cancer marker. If elevated, cancer risk increases, but it can also be elevated in benign conditions like endometriosis, pregnancy, or inflammation.
- Pregnancy test: To rule out ectopic pregnancy.
- Hormone tests: To evaluate PCOS or other hormonal problems.
MRI or CT. If ultrasound doesn't provide enough information or the mass is complex, more detailed imaging is done.
Laparoscopy. The abdomen is examined with a thin camera. It's used for both diagnosis and treatment. The doctor can remove small masses or take a biopsy during the same procedure.
Biopsy. If the mass is suspicious, a tissue sample is taken and examined under a microscope. This gives a definitive diagnosis.
During diagnosis, your doctor evaluates:
- The mass's size
- Whether it's solid or fluid-filled
- Whether it's one-sided or on both sides
- Whether it has regular or irregular borders
- Your age and menopausal status
- Your symptoms
- Blood test results
This information helps determine what the mass is and how it should be treated.
Treatment
Treatment varies depending on the mass type, size, symptoms, and your age.
Watchful waiting. This is usually the first approach for small, simple-appearing cysts. Especially in women of reproductive age, functional cysts disappear on their own within 2-3 months. Your doctor will request a repeat ultrasound after a few months. If the cyst has shrunk or disappeared, nothing is done. This approach avoids unnecessary surgery.
Birth control pills. Birth control pills are recommended to prevent recurrent functional cysts. These pills stop ovulation, preventing new cyst formation. They don't shrink existing cysts but prevent new ones from forming.
Pain control. If the mass is causing pain, pain relievers like ibuprofen or acetaminophen are recommended.
Surgery. Surgery is needed in these situations:
- If the cyst is large (usually over 5-10 cm)
- If the cyst is solid or has complex content
- If the cyst doesn't disappear in 2-3 months
- If there's cancer suspicion
- If there are severe symptoms
- In postmenopausal women with a cyst
- If there's ovarian torsion or rupture
Surgical options:
- Laparoscopy (Minimally invasive surgery): Small incisions are made in your abdomen and the cyst is removed with thin instruments. Recovery is quick, usually you go home the same day or next day. Preferred for small cysts.
- Laparotomy (Open surgery): A larger incision is made in the abdomen. Preferred for large masses or if cancer is suspected. Recovery takes longer.
During surgery, if possible only the cyst is removed and the ovary is preserved (cystectomy). However, in some cases the entire ovary is removed (oophorectomy). If both ovaries are removed, you enter early menopause.
Chemotherapy and radiation. If the mass turns out to be cancerous, oncology treatments are needed.
Complications
Most adnexal masses don't cause complications. However, some situations can develop:
- Ovarian torsion. If the mass weighs down the ovary, the ovary can twist around its own axis. This cuts off blood flow and causes severe pain. Emergency surgery is needed. If delayed, the ovary dies and must be removed.
- Cyst rupture. A cyst can burst. When small cysts rupture, usually there's just mild pain and it resolves on its own. When large cysts rupture, fluid or blood spills into the abdomen and severe pain, fever, and infection risk occur.
- Bleeding. Some cysts cause internal bleeding when they rupture. If there's heavy bleeding, surgery is needed.
- Infection. Masses arising from pelvic inflammatory disease especially can form abscesses. If untreated, infection can spread.
- Infertility. Endometrioma and recurrent cysts can cause infertility. Especially if both ovaries are affected or if surgery damages the ovaries, natural pregnancy becomes difficult.
- Cancer. Rare but the most serious complication. If the mass is cancerous, early detection is very important.
Prevention
Not all adnexal masses can be prevented because some are part of the natural hormonal cycle.
However, some measures can reduce risk:
- Use birth control pills. Long-term birth control pill use reduces functional cyst formation. It also lowers ovarian cancer risk.
- Maintain hormonal balance. If you have hormonal problems like PCOS, get treatment.
- Regular gynecological exams. Go for gynecological checkups once a year. Small masses can be detected early.
- Healthy weight. Being overweight creates hormonal imbalance and increases PCOS risk.
- Treat endometriosis. If you have endometriosis, get treatment. This can reduce endometrioma formation.
- Protect against sexually transmitted infections. Use condoms and practice safe sex. This reduces pelvic inflammatory disease risk.
- Genetic counseling. If there's ovarian cancer history in the family, get genetic testing. If you have a BRCA mutation, preventive measures can be discussed.
Living with Adnexal Masses
When you're diagnosed with an adnexal mass, it's normal to worry. But remember that most masses are harmless and treatable. From the moment of diagnosis, taking good care of yourself both emotionally and physically is important.
Coping Emotionally
Thinking "Is it cancer?" may be the first thing that comes to mind when you're diagnosed. This is a completely normal reaction. But statistics are encouraging: In women of reproductive age, 90 percent of masses are benign. In postmenopausal women this rate drops a bit but most masses are still harmless.
Getting information is one of the most effective ways to reduce your anxiety. Ask your doctor questions about your mass's type, size, cancer risk, and treatment options. The more you know, the more control you feel over the situation. Ask them to explain medical terms you don't understand - this is your right.
Talking with people around you can also be comforting. Tell your family and close friends about your condition. You can meet with women who've had similar experiences in online or in-person support groups. Sometimes just feeling "I'm not alone" makes a big difference.
If a watchful waiting approach has been recommended, this waiting period can be challenging. You might think "Why aren't we doing something right away?" But this approach is to avoid unnecessary surgery because most functional cysts disappear on their own. Go to your regular checkups and track changes - this is an active process, not passive waiting.
Managing Pain
If the mass is causing pain, it can affect your daily life. But there are ways to manage pain. Placing a hot water bottle on your lower abdomen reduces muscle tension and provides relief. Heat application is especially helpful during your period or when pain increases.
Use the pain relievers your doctor recommends regularly. Over-the-counter medications like ibuprofen or acetaminophen can control mild to moderate pain. If pain is very severe or pain relievers aren't working, definitely tell your doctor - this could be a sign of worsening.
Listen to your body. When you have pain, don't push yourself, rest. Some days may be more challenging and that's normal. Don't hesitate to request flexibility at work or ask for help.
Nutrition and Lifestyle Changes
A special diet won't shrink or eliminate a cyst, but it supports your overall health and can ease some symptoms. A fiber-rich diet is especially important. Vegetables, fruits, whole grains, and legumes prevent constipation. If the mass is pressing on the bowels, constipation can seriously increase pain, so keeping your digestive system regular is important.
Try to drink at least 8 glasses of water a day. Good hydration reduces bloating and generally makes you feel better. Choose water, herbal teas, or fresh-squeezed fruit juices over caffeinated beverages.
Antioxidant-rich colorful vegetables and fruits can help reduce inflammation in the body. Tomatoes, carrots, spinach, and blueberries are good choices. Also avoiding processed foods, excess sugar, and trans fats helps maintain hormonal balance.
Exercise and Physical Activity
Gentle, regular exercise increases blood circulation, reduces stress, and improves your overall health. Walking is one of the safest and easiest options. You can do 20-30 minutes of brisk walking daily. Swimming is also excellent exercise that works the whole body without putting stress on joints.
Yoga and gentle stretching exercises are beneficial both physically and emotionally. They reduce muscle tension, increase flexibility, and help you relax. However, avoid inverted poses or positions that put too much pressure on the abdominal area.
You need to avoid some activities. Running, jumping, heavy lifting, or intense abdominal exercises can cause the cyst to twist (torsion). These risks increase especially if you have a large cyst. Definitely ask your doctor which exercises are safe for you.
If your body is telling you something, listen. If you feel pain, cramping, or discomfort during exercise, stop immediately. Mild tiredness after exercise is normal but severe pain is not part of normal.
Sexual Life and Relationships
If you're experiencing pain during sexual intercourse because of the mass, there's nothing to be ashamed of and it's quite common. Talking openly with your partner is very important. When you explain the situation, most partners will be understanding and supportive.
Starting intercourse without rushing, when you're relaxed, reduces pain. If intercourse is very painful, postponing sexual activity for a while is also an option. This is a temporary situation and when the mass is treated or disappears, your sex life will return to normal.
Pregnancy Planning
If you're planning pregnancy, definitely discuss your situation with your doctor. The good news is that most adnexal masses don't prevent pregnancy. Small functional cysts usually have no effect on pregnancy and in fact having a cyst in the first months of pregnancy is quite normal.
However, if you have conditions like endometrioma or PCOS, getting pregnant naturally may become more difficult. In these situations, fertility treatments or treating the cyst first may be needed. Your doctor will recommend the most appropriate approach for you.
If you're already pregnant and a mass is detected, don't worry. Small corpus luteum cysts are very common in the first three months of pregnancy and usually disappear on their own in the second trimester. Your doctor will do regular monitoring with ultrasound. Large cysts rarely create torsion risk, in which case if necessary, surgery can be done safely in the second trimester.
If you need surgery and want children in the future, discuss fertility openly with your doctor. Surgeons try to preserve ovarian tissue as much as possible. Even if one ovary is removed, the other works normally and you can get pregnant. However, in rare cases if both ovaries must be removed, discuss egg freezing options with your doctor before surgery.
Regular Follow-up and Checkups
Following your doctor's recommended follow-up program is vitally important. If you're on watchful waiting, a follow-up ultrasound is usually done 4-8 weeks later. This ultrasound shows whether the cyst has shrunk or disappeared. If you've had surgery, you'll have a checkup appointment 2-4 weeks later.
These checkups evaluate not just the cyst's status but your overall gynecological health. Don't postpone or skip your checkups. Early detection always gives better results. You can also periodically feel your abdomen yourself - if you notice abnormal swelling or hardness, call your doctor.
If you notice any change in your symptoms, tell your doctor immediately. If pain is increasing, new symptoms are appearing, or abdominal swelling is growing, make an appointment without waiting for the next checkup. Your body can give you important signals.
Work Life and Daily Routines
If the mass is affecting your daily life, you may need to make some arrangements at work. If you have pain, talk with your manager and if necessary request flexible work hours or work-from-home options. Taking short breaks and getting up and walking around periodically both reduces pain and improves circulation.
Avoid lifting heavy objects. If your workplace has tasks requiring heavy lifting, ask for help during this time. Tight, restrictive clothing can put pressure on the abdominal area, so prefer comfortable, loose clothing. Elastic-waist pants or skirts will be more comfortable.
If you're planning long trips, consult your doctor. If you have a large cyst, pressure changes during air travel can create discomfort. On long car trips, stop and walk around frequently. Always carry pain relievers with you - they can be useful in emergencies.
Stress Management and Mental Health
Living with a chronic health issue, being in a watchful waiting process, or the pre-surgery period can be stressful. Stress management is important for both your overall health and your symptoms because stress can increase pain and weaken your immune system.
Deep breathing exercises are a simple but effective technique you can practice several times a day. Breathe in deeply through your nose, hold for a few seconds, and slowly exhale through your mouth. This calms the nervous system. Meditation practices similarly provide mental peace - you can use apps to get started.
Pay attention to your sleep routine. 7-8 hours of quality sleep each night is essential for your body to repair itself. Set regular sleep hours and keep your bedroom comfortable, dark, and quiet. Reduce screen use before bed.
Make time for yourself and engage in activities you enjoy. Reading books, listening to music, working in the garden, painting - do whatever makes you happy. Sometimes getting away from daily stress and resting your mind is the best medicine.
Recognizing Emergencies
If you're on watchful waiting or waiting for surgery, some symptoms may require emergency care. Sudden, severe abdominal or pelvic pain may be a sign of ovarian torsion or cyst rupture. This pain is usually very different from mild cramping - it's sharp, unbearable, and starts suddenly.
Fever (over 38°C) may be a sign of infection, especially if accompanied by pain and tenderness. Nausea and vomiting together with severe pain may be a sign of complications. Fainting, dizziness, or rapid heartbeat may be signs of internal bleeding.
If you experience any of these symptoms, go to the nearest emergency room. Ovarian torsion especially is a time-critical situation - the earlier the intervention, the better the chance of saving the ovary.
Symptoms requiring emergency room visit:
- Sudden, severe, unbearable pain
- Fever over 38°C
- Severe nausea and vomiting
- Fainting or dizziness
- Rapid heartbeat or shortness of breath
- Abdominal rigidity or swelling
Preparing for Your Appointment
What you can do:
- Note your symptoms: When they started, how you're feeling, how severe pain is if present
- Track your menstrual period: Last period date, whether regular or not
- Prepare your past medical history: If you've had cysts or surgery before, medications you use
- Family history: Note if there's ovarian cancer, endometriosis, or PCOS in the family
- Write down your questions: Note what comes to mind
Questions you can ask your doctor:
- What type is my mass?
- What's its size?
- Is there cancer risk?
- Is watchful waiting appropriate or is treatment needed?
- If surgery is needed, will my ovary be preserved?
- Will it affect my fertility?
- For which symptoms should I contact you?
- How often should I come for checkups?
- What do you recommend for my pregnancy plans?
Your doctor may ask you:
- What are your symptoms? When did they start?
- Is there pain? Where and how severe?
- Are your periods regular?
- Is there a chance you're pregnant?
- Have you had cysts or pelvic problems before?
- Is there ovarian cancer history in the family?
- What medications are you taking?
- Are you using birth control?
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2- Adnexal Masses: Diagnosis and Management — https://pubmed.ncbi.nlm.nih.gov/38215419/
3- Initial Investigation and Management of Adnexal Masses — https://pubmed.ncbi.nlm.nih.gov/32736853/
4- Adnexal mass: diagnosis and management — https://pubmed.ncbi.nlm.nih.gov/21606754/
5- Practical Recommendations for the Management of Benign Adnexal Masses —https://pubmed.ncbi.nlm.nih.gov/32559804/